Our laboratory combines state-of-the-art proteomics technology with basic biological research and systems biology for the study of cancer progression and cancer metabolism.
The multistep process of cancer progression involves dramatic phenotypic changes in cell growth, survival, invasiveness and metabolism. To understand the mechanisms of these changes, global ‘omics’ approaches examine the molecular changes in a system-wide manner.
Mass spectrometry-based proteomics aims to achieve a global view of the biological system through identification and quantification of the proteins and their modification. Mass spectrometry-based proteomics is the mainstream proteomics approach, which can be applied to a wide variety of biological systems.
Our main focus is the study of breast cancer progression through investigation of the proteomes of cancer cell lines and clinical samples. We aim to understand the mechanisms of breast cancer progression and metabolic remodeling, to find novel drug targets and cancer markers.